The efficacy of CD19-specific CAR T cells in the treatment of leukemia/lymphoma relies, at least in part, on the unique properties of the particular CAR and the presence of healthy B cells that enhance the target cell lysis and cytokine secretion through repetitive stimulation.Here, we report to apply the same CAR to target solid tumors, such as Er
Over 5.5 million tons of plastic waste are generated globally from the research sectors.A university laboratory, e.g., pathology, can generate 250 tons of clinical plastic waste annually.The UK National Health Service (NHS) generates 133 kilotons (kt) of clinical plastic waste annually.Healthcare facilities in the US generate 1.7 million tons of cl
The expansion of Brazilian agriculture has led to a heavy dependence on imported fertilizers to ensure the supply of the growing food demand.This fact has contributed to a growing interest in alternative nutrient sources, such as ground silicate rocks.It is necessary, however, to know the potential of nutrient release and changes these materials ca
Objectives To understand how and under what circumstances midwife-led continuity of care (MLCC) can be implemented in high-income countries.Design A realist review was conducted to examine interactions between contexts, mechanisms and outcomes.Methods An initial programme theory described a hypothesis of how MLCC might be implemented successfully.L